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A randomized controlled study for the efficacy and safety of nebulized hypertonic saline in the treatment of moderate to severe bronchiolitis in infants with CPAP

A randomized controlled study for the efficacy and safety of nebulized hypertonic saline in the treatment of moderate to severe bronchiolitis in infants with CPAP

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900023271
Enrollment
Unknown
Registered
2019-05-20
Start date
2019-10-01
Completion date
Unknown
Last updated
2019-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bronchiolitis

Interventions

experimental group:hypertonic saline inhalation + CPAP assisted ventilation + conventional treatment
control group:CPAP assisted ventilation + conventional treatment

Sponsors

Respiratory Department, Children’s Hospital, Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Children meeting the diagnostic criteria for bronchiolitis of the eighth edition of Zhu Futang practical pediatrics; Aged less than 2 years, male or female, with moderate to severe disease severity score; Obtain the consent of the patient's parents and sign the informed consent.

Exclusion criteria

Exclusion criteria: Premature delivery, congenital heart disease, immune deficiency, bronchopulmonary dysplasia, congenital tracheobronchial malformation, foreign body inhalation, chronic lung disease were excluded. Children with contraindications to CPAP were excluded.

Design outcomes

Primary

MeasureTime frame
Clinical symptom score;The time of wheezing disappear;Total hospital stay;adverse reaction;—

Countries

China

Contacts

Public ContactDai Jihong

Children’s Hospital, Chongqing Medical University, Chongqing

danieljh@qq.com+86 13708372373

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026