Supine hypotension syndrome
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: singleton pregnancy at term via elective cesarean section; age from 18 to 40 years; height from 150 cm to 180 cm; American Society of Anesthesiologists (ASA) grade from I to II grade; and BMI less than 35 kg/m2.
Exclusion criteria
Exclusion criteria: Transverse lie, fetal macrosomia, uterine abnormalities (e.g., large fibroids, bicornuate uterus) and polyhydramnios, ruptured membranes, oligohydramnios, or intrauterine growth restriction; Women with gestational or nongestational hyptertension, diabetes, eclampsia, a hypertensive disorder or any condition associated with autonomic neuropathy (e.g., diabetes mellitus for more than 10 yr), with renal failure; Women have contraindications for spinal anesthesia; participants refused to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Umbilical artery blood pH; | — |
Secondary
| Measure | Time frame |
|---|---|
| umbilical vein blood PH;umbilical artery blood partial pressure of oxygen;umbilical vein blood partial pressure of oxygen;umbilical artery blood BE;umbilical vein blood BE;umbilical artery blood HCO3-;umbilical vein blood HCO3-;fetal Apgar score (1 minute after birth) And 5 minutes);The incidence of nausea in pregnant women;The incidence of vomiting in pregnant women;The incidence of hypotension in pregnant women;The incidence of hypertension in pregnant women;The incidence of bradycardia in pregnant women;2 min (T1), 4 min (T2), 6 min (T3), 8 min (T4), 10 min (T5), 12 min (T6), 14 min (T7), 16 min (T8), 18 min (T9) , 20min (T10) blood pressure after subarachnoid injection;2 min (T1), 4 min (T2), 6 min (T3), 8 min (T4), 10 min (T5), 12 min (T6), 14 min (T7), 16 min (T8), 18 min (T9) , 20min (T10) heart rate after subarachnoid injection;Dosage and frequency of phenylephrine during surgery;Time interval from the completion of combined spinal and epidural anesthesia to the first use of phenylephrine;The time interval from the injection of the subarachnoid space to the delivery of the fetus;Skin incision to fetal delivery interval;Uterine incision to fetus delivery time interval;Dosage and frequency of epidural bupivacaine during surgery;Dosage and frequency of ephedrine during surgery;Dosage and frequency of atropine during surgery; | — |
Countries
China
Contacts
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University