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Clinical study for the relationship between the transcription level and protein expression level of blood muc5ac and muc5b and clinical efficacy and pulmonary function in children with bronchial asthma

Clinical study for the relationship between the transcription level and protein expression level of blood muc5ac and muc5b and clinical efficacy and pulmonary function in children with bronchial asthma

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900023208
Enrollment
Unknown
Registered
2019-05-16
Start date
2019-05-14
Completion date
Unknown
Last updated
2019-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Interventions

asthma group:no intervention
healthy group:no intervention

Sponsors

Jihong Dai
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 14 Years

Inclusion criteria

Inclusion criteria: Healthy control group: children aged 11-14 years; no abnormal physical examination; no abnormalities in blood routine. Asthma group: children aged 11-14 years; children diagnosed with bronchial asthma for the first time in the outpatient clinic based on guidelines for prevention and treatment of bronchial asthma.

Exclusion criteria

Exclusion criteria: Healthy control group: There are other system diseases in the past 1 month and there are other systematic chronic disease history; Asthma group: with other diseases causing abnormal expression of mucin (muc5ac, muc5b), chronic obstructive pulmonary disease, cystic fibrosis, allergic rhinitis, sinusitis, nasal polyps, otitis media, gallstones, tumors Disease, dry eye, idiopathic pulmonary fibrosis, diffuse panbronchiolitis. Regular anti-asthma treatment within 1 month before the first visit.

Design outcomes

Primary

MeasureTime frame
RNA expression level of MUC5AC;RNA expression level of MUC5B;protein expression of MUC5AC in Plasma;protein expression of MUC5B in Plasma;—

Countries

China

Contacts

Public ContactJihong Dai

Children's Hospital of Chongqing Medical University

2392463929@qq.com+86 18883370210

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026