gastroesophageal reflux disease
Conditions
Interventions
Sponsors
Shanghai Municipal Hospital of Shanghai TCM University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patient with gastroesophageal reflux disease more than 3 months; 2. Dependence on PPI, that is, those who have taken PPI for more than 2 months, but could not withdraw, and occurred reflux or other symptoms after more than 3-day withdrawal; 3. Male or female aged 18 to 70 years; 4. The voluntary participation in the trial, informed consent, and signed the agreement.
Exclusion criteria
Exclusion criteria: 1. The pregnant or lactating women; 2. The combination of the following diseases: suspected or proven malignant tumor, peptic ulcer, esophageal and gastric or duodenal surgery, Zollinger Ellison syndrome, primary esophageal motility disorders (such as achalasia, scleroderma, primary esophageal spasm), upper gastrointestinal malignant disease, drug-induced esophageal inflammation, pyloric obstruction; 3. The serious cardiovascular disease, liver and kidney dysfunction; 4. There is psychotic or language disorder; 5. It is not partners (that cannot match the diagnosis or not according to the provisions of medication and influence curative effect).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RDQ;Clinical symptom score; | — |
Secondary
| Measure | Time frame |
|---|---|
| GERD-HRQL;SF-36; | — |
Countries
China
Contacts
Public ContactLingyun Zhu
Department of Gastroenterology, Shanghai Municipal Hospital of Shanghai TCM University
Outcome results
None listed