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Clinical study for improvement of intestinal microbiota disorder caused by tyrosine kinase inhibitor with Chinese medicine

Clinical study for improvement of intestinal microbiota disorder caused by tyrosine kinase inhibitor with Chinese medicine

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900023194
Enrollment
Unknown
Registered
2019-05-16
Start date
2019-06-04
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

malignant tumor

Interventions

No diarrhea group:Nothing

Sponsors

Changhai Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. The clinical or pathological diagnosis was malignant tumor. 2. Male or female aged older than 18 years. 3. The patient was not given antibiotics for nearly 4 weeks. 4. Diarrhea patients who have received tyrosine kinase inhibitors (sorafenib, apatinib, and lenvatinib etc). 5. The expected survival time is more than 8 weeks. 6. Willing to participate in clinical trials and sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with clear digestive and absorption dysfunction, or with active gastrointestinal bleeding, intestinal obstruction, intestinal perforation tendency, or inability to receive oral medication for any reason. 2. Diabetes mellitus. 3. Obesity. 4. There are severe renal insufficiency, blood creatinine >200ummol/L, or with other serious visceral diseases. 5. Bacterial enteritis, dysentery, severe dehydration, malnutrition and other systemic diseases. 6. The researcher thinks it is not suitable for this study.

Design outcomes

Primary

MeasureTime frame
Fecal flora;

Countries

China

Contacts

Public ContactXiaofeng Zhai

Changhai Hospital

zhxfch@163.com+86 021 31161950

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026