Primary Nephrotic Syndrome
Conditions
Interventions
SSNS :?
FRNS/SDNS :?
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
0.5 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1) the onset age was from half a year to 18 years old, and the follow-up of our hospital was more than 3 years; (2) primary nephrotic syndrome (PNS), diagnostic criteria: quantitative 50mg/kg of proteinuria at 24h, or quantitative 50mg/kg of morning urine protein/creatinine (mg/mg) 2.0, 3 times a week (+++-++++ +). Hypoproteinemia: serum albumin is less than 25g/L; Hyperlipidemia: serum cholesterol was higher than 5.7mmol/L.Varying degrees of edema. In the above four items, 1 and 2 are the necessary conditions for diagnosis; (3) Hormone-sensitive NS: patients treated with prednisone at 2mg/(kg.d) or 60mg/(mm2.D) for less than 4 weeks of urine protein negative conversion were followed up for more than 3 years for recurrence. Steroid-dependent/recurrent NS: sensitive to hormones, but with two consecutive dose reduction or drug withdrawal within 2 weeks of recurrence, the duration of the disease shall be no less than 2 times of recurrence within half a year, or no less than 4 times of recurrence within 1 year.SSNS noted that delayed SRNS was excluded during follow-up.
Exclusion criteria
Exclusion criteria: 1. patients with obvious hormone side effects, intolerance to hormones or hormone contraindications were excluded; 2. nephritic nephrotic syndrome (NNS) was excluded, i.e., one or more of the following four items: (1) Three centrifugal uroscopy examinations of erythrocyte > 10/high power microscopic field of vision (HP) were performed within 2 weeks, respectively, and confirmed to be glomerulogenic hematuria; (2) repeated or sustained hypertension 3 at different time points measured systolic blood pressure and/or diastolic blood pressure is greater than the same gender, age and height of children and adolescents of the 95th percentile of blood pressure, and the exception of glucocorticoid and other reasons; (3) renal dysfunction, and excluded due to insufficient blood volume; (4) persistent low complement blood disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Genetic variants; | — |
Countries
China
Contacts
Public ContactHaiping Yang
Children's Hospital of Chongqing Medical University
Outcome results
None listed