Primary Nephrotic Syndrome
Conditions
Interventions
SSNS:?
SRNS :?
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
0.5 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1) the onset age was from half a year to 18 years old, and the follow-up time was more than 3 years; (2) primary nephrotic syndrome (PNS) was established with the diagnostic criteria of hyperproteinuria: quantitative 50mg/kg of 24h proteinuria or quantitative 50mg/kg of morning urine protein/creatinine (mg/mg) 2.0, and qualitative assessment of morning urine protein (+++-++++) 3 times a week. Hypoproteinemia: serum albumin is less than 25g/L; Hyperlipidemia: serum cholesterol was higher than 5.7mmol/L. Varying degrees of edema. In the above four items, 1 and 2 are the necessary conditions for diagnosis; (3) hormone-sensitive NS: patients treated with prednisone at 2mg/(kg.d) or 60mg/(mm2. D) for less than 4 weeks of urine protein conversion without recurrence and with stable condition for more than 3 years. Steroid-resistant NS: those whose urinary protein is still positive after prednisone treatment for more than 4 weeks are further divided into initial drug resistance and late drug resistance. The latter refers to that > urinary protein is still positive after hormone treatment for 1 or more times of remission.
Exclusion criteria
Exclusion criteria: 1. patients with obvious hormone side effects, intolerance to hormones or hormone contraindications were excluded.(2) nephritic nephrotic syndrome (NNS) was excluded, i.e., one or more of the following four items: (1) Three centrifugal uroscopy examinations of erythrocyte > 10/high power microscopic field of vision (HP) were performed within 2 weeks, respectively, and confirmed to be glomerulogenic hematuria; (2) repeated or sustained hypertension 3 at different time points measured systolic blood pressure and/or diastolic blood pressure is greater than the same gender, age and height of children and adolescents of the 95th percentile of blood pressure, and the exception of glucocorticoid and other reasons; (3) renal dysfunction, and excluded due to insufficient blood volume; (4) persistent low complement blood disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Genetic variants; | — |
Countries
China
Contacts
Public ContactHaiping Yang
Children's Hospital of Chongqing Medical University
Outcome results
None listed