vascular dementia
Conditions
Interventions
Experimental group:Hengqing I formula
Nimodipine group:Nimodipine tablet
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: The diagnosis of vascular dementia by American psychiatric diagnostic and statistical manual (DSM-IV- R, 1994) diagnostic criteria of vascular dementia. Eligible participants should meet both the following items: Dementia: Firstly, pass through clinical examination and neuropsychological evaluation means, to determine the cognitive level of patients with a significant decline in the previous, including: (1) memory defects (unable to learn new information, or unable to recall previously mastered information); (2) cognitive field of two or more disorders: aphasia, apraxia (can not perform action, even if the patient does not have motor dysfunction), loss Recognize (cannot recognize or recognize objects, even if the patient does not have sensory dysfunction), executive management dysfunction (that is, planning, organization, abstraction, order, etc.); (3) the above two kinds of defects are not caused by cerebrovascular disease itself, but also has been very serious, affecting the patient's daily life, activity ability. Cerebrovascular disease: (1) confirmed by the nervous system examination, the patient has focal signs caused by cerebrovascular disease, including hemiplegia, blindness, sensory disorders, central facial paralysis, pathological signs; (2) no focal signs, but there is imaging examination (head CT or MRI) confirmed evidence of cerebrovascular disease, such as multiple large blood vessel infarction or a single key location of the infarction, as well as multiple base Basal ganglia and lacunar white matter infarcts, or extensive periventricular white matter damage, or coexistence of these lesions. The above two kinds of damage have causal relationship, that is, the existence of the following relationship:(2) or a sudden decline in cognitive function, or its cognitive impairment shows fluctuations like, ladder like damage. (1) meet the above criteria for diagnosis of dementia and mild to moderate clinical diagnosis; (2) the onset time of cerebrovascular disease was clear, imaging supported the diagnosis of infarction and hemorrhage, and dementia appeared within 3 months and lasted for 3 months; (3) Hachinski ischemia score (HDS score standard (3)) >=7; (4) except for dementia caused by other reasons.
Exclusion criteria
Exclusion criteria: (1) patients with alzheimer's disease (AD) or other types of dementia and severe VD; (2) patients with severe cardiac, pulmonary and renal dysfunction, severe diabetes mellitus and a history of mental illness; (3) those who have received systematic treatment of Chinese and western medicine in near past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA scale;Hasegawa dementia scale, HDS;HIS;Minimum Mental State Examination, MMSE;ADAS-Cog scale;Activity of Daily Living Scale, ADL; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum total cholesterol;triglyceride;high density lipoprotein cholesterol;low density lipoprotein cholesterin;SDSVD; | — |
Countries
China
Contacts
Public ContactShengxi Meng
Shanghai Sixth People's Hospital
Outcome results
None listed