autoimmune diseases
Conditions
Interventions
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
10 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 10-70 years; 2. Expected survival beyond 12 weeks; 3. Patients with autoimmune diseases diagnosed by physical examination, pathological examination, laboratory examination and imaging. The curative effect of conventional treatment is poor, and there is no effective treatment. 4. Creatinine 50; 8. Patients can understand and voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients in pregnancy or breast-feeding period; Planning pregnancy within 6 months; 2. HIV or active TB infected or active hepatitis B or hepatitis C infection; 3. Feasibility assessment during screening demonstrates <10% transduction of target lymphocytes, or insufficient expansion (<5-fold) in response to CD3/CD28 costimulation; 4. Patients with abnormal vital signs or could not cooperate with inspectors; 5. History of mental disorders; 6. Highly allergic constitution or severe allergies, especially allergic to IL-2; 7. Systemic infection or serious infections should be local anti-infection treatment; 8. With heart, lung, brain, liver, kidney and other important organ dysfunction; 9. Other situations we think improper for the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of antibody;Index of disease activity;The degree of improvement of clinical symptoms;Safety; | — |
Countries
China
Contacts
Public ContactKailin Xu
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed