Healthy subjects
Conditions
Interventions
Case series:genotype
Sponsors
Clinical Pharmacology Institution, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. healthy volunteers aged between 18 and 40, including boundary value;The age difference of the same batch shall not exceed 10 years; 2. if the body weight is more than 50 kg, the body mass index (BMI) of the subject is between 19 kg/m2 and 24 kg/m2, including the boundary value. The difference in body weight of the same batch should not be too large. 3. the subject is willing to participate in the test voluntarily and perform the test in accordance with the procedures specified in this test; 4. sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. patients with diseases of clinical significance or who have received surgery within 4 weeks before the trial; 2. there is any abnormality with clinical significance in the results of laboratory examination; 3. have used drugs with known damage to certain organs within 3 months or are currently using drugs; 4. have a history of drug allergy and high sensitivity to environmental substances; 5. susceptible to hypokalemia; 6. congestive heart failure, gastric ulcer, deficiency of glucose-6-phosphate dehydrogenase (G6PD), severe liver function impairment, and severe renal function impairment; 7. patients with a history of any other serious clinical diseases or diseases of cardiovascular system, endocrine system, nervous system or lung, hematology, immunology, psychiatric diseases and metabolic abnormalities; 8. those with recent colds; 9. patients with active bleeding, diabetes, glaucoma and other diseases; 10. HIV-positive persons; 11. hepatitis B surface antigen test positive or hepatitis C test positive; 12. an accompanying therapist of any medical significance is being performed; 13. patients with concomitant medication within 14 days prior to participating in this study; 14. have a history of drug abuse; 15. soft drugs (e.g. cannabis) taken 3 months before and during the study, or hard drugs (e.g. cocaine, benzodiazepine, etc.) taken 1 year before and during the study; 16. those who have participated in other drug trials within 3 months; 17. blood donors within 3 months before the test; 18. patients with coagulopathy or thromboembolic disease. 19. people with cold stomachs. 20. With history of drug allergy; 21. With smoke and alcoholic habits; 22. abnormal findings in physical examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| medicine generation power curve; | — |
Countries
China
Contacts
Public ContactZhirong Tan
Clinical Pharmacology Institution, Central South University
Outcome results
None listed