The study for effect of analgesics and/or sedation on the autoimmune status and prognosis of patients in neurologic ICU

The prospective randomized clinical trial for comparing the effect of revised EGDS and sequential analgesics and/or sedation on the prognosis of patients in neurologic ICU

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900023130

Enrollment

Unknown

Registered

2019-05-13

Start date

2019-04-30

Completion date

Unknown

Last updated

2019-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

severe neurologic diseases

Interventions

Control group:non-pharmaceutical

re-EGDS group 1:dexmedemetomidine

SAA?:sequential analgesics and/or sedation

re-EGDS group 2:dexmedemetomidine+remifentany

re-EGDS group 3:Remifentanyl+Midazolam/Diazepam/Propofol

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. 18years 3, and APACHE II score < 25; 3. Hospitalized due to newly developed neurological diseases and expected ICU stay is more than 3 days.

Exclusion criteria

Exclusion criteria: Exclusion criteria 1. Prescribed with sedatives or analgesia before admission; 2. Status epilepticus; 3. Intracranial tumor; 4. High-dose vasoactive agents to maintain MBP (norepinephrine>2ug/min, or Dopamine>5ug/kg/min); 5. Bradycardia; 6. Pathologic pain; 7. Chronic renal failure, acoholism or histaor of taking antipsychotic agents; 8. Hiatory of sedatives or analgesia allergy ((propofol, midazolam, remifentanyl or dexmedetomidine).

Design outcomes

Primary

Measure	Time frame
best controlled RASS;Hours spent to RASS target;	—

Secondary

Measure	Time frame
mortality;coma;delirium;ventilation need;mortality;hospitalization;excubation;falling;	—

Countries

China

Contacts

Public ContactFeng Huiyu

The First Affiliated Hospital of Sun Yat-sen University

mgsysu@163.com+86 13247594957

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026