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Determination of the 90% effective dose of intermittent intravenous phenylephrine for the treatment of spinal anesthesia-induced hypotension in parturients undergoing cesarean delivery: a sequential allocation dose-finding study

Determination of the 90% effective dose of intermittent intravenous phenylephrine for the treatment of spinal anesthesia-induced hypotension in parturients undergoing cesarean delivery: a sequential allocation dose-finding study

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900023120
Enrollment
Unknown
Registered
2019-05-12
Start date
2019-05-13
Completion date
Unknown
Last updated
2019-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean delivery

Interventions

Case series:phenylephrine

Sponsors

Women's Hospital, Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patients aged 18-40 years without pregnancy complications.

Exclusion criteria

Exclusion criteria: 1. had a contra-indication to spinal anaesthesia; 2. in active labour; 3. placenta previa or other placental abnormality; 4. had a multiple pregnancy; pulmonary oedema; 5. had a BMI > 40 kg.m2; umbilical cord prolapse; 6. with cardiovascular and cerebrovascular diseases; 7. refuse to sign the informed consent.

Design outcomes

Primary

MeasureTime frame
successful responses to phenylephrine;—

Secondary

MeasureTime frame
Fetal outcomes (the outcomes of the analysis of umbilical vein blood gas; Apgar score at 1 and 5 min);—

Countries

China

Contacts

Public ContactXiaowei Qian

Women's Hospital, Zhejiang University School of Medicine

qianxw@zju.edu.cn+86 15700157161

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026