severe pre-eclampsia
Conditions
Interventions
group R-1:phenylephrine 40µg
group R-2:phenylephrine 50µg
group R-3:phenylephrine 60µg
group R-4:phenylephrine 70µg
group R-5:phenylephrine 80µg
group C-1:phenylephrine 70µg
group C-2:phenylephrine 80µg
group C-3:phenylephrine 90µg
group C-4:phenylephrine 100µg
group C-5:phenylephrine 110µg
Sponsors
Women's Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: The research group(group R): Patients with severe early onset preeclampsia (systolic blood pressure > 160 mmHg and/or diastolic blood pressure > 110 mmHg, on = 2 separate occasions; or symptoms of imminent eclampsia (headache, visual disturbance, epigastric pain) with = 3 + proteinuria. The controll group(group C): Patients aged 18-40 without hypertension or any other pregnancy complications.
Exclusion criteria
Exclusion criteria: We do not recruit patients if they had a contra-indication to spinal anaesthesia; were in active labour; placenta previa or other placental abnormality; had a multiple pregnancy; pulmonary oedema; had a BMI > 40 kg.m2; umbilical cord prolapse; refuse to sign the informed consent.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Maternal outcomes (Nausea and Vomiting; Bradycardia; Tachycardia; Hypertension; Dizzy; Dyspnea); | — |
Primary
| Measure | Time frame |
|---|---|
| successful responses to phenylephrine; | — |
Countries
China
Contacts
Public ContactXiaowei Qian
Women's Hospital, Zhejiang University School of Medicine
Outcome results
None listed