Heart disease
Conditions
Interventions
Control group:none
Experimental group:Tissue oxygen monitoring
Sponsors
Tianjin Chest Hospital
Eligibility
Sex/Gender
Male
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Adult patients = 50 years old; 2) Scheduled for isolated off-pump CABG with median sternotomy under general anesthesia with endotracheal intubation.
Exclusion criteria
Exclusion criteria: 1) Having a concomitant cardiac procedure associated with CABG; 2) Emergency CABG surgery (i.e., immediate revascularization for hemodynamic instability); 3) Redo CABG; 4) Acute cardiovascular event, including acute or decompensated heart failure and acute coronary syndrome; 5) Circulatory shock; 6) Preoperative sepsis; 7) Chronic kidney disease with glomerular filtration rate < 30 ml/min/1.73 m2 or requiring renal-replacement therapy for end-stage renal disease; 8) Participation in another competing treatment study; 9) Refusal to participate; 10) Pregnant or breastfeeding women; 11) Muscular dystrophy or atrophy (with a potential to interfere with muscular tissue oxygen saturation monitoring); 12) Skin conditions incompatible with the adhesive oximetry probe.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| systemic inflammatory response syndrome;at least 1 organ system injury or dysfunction occurring within day 7 after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in hemodynamic variables;individual components of the primary composite outcome;the SOFA score on days 1, 2, and 7;postoperative complications;durations of intensive care unit and hospital stay;all-cause mortality at 30 days after surgery; | — |
Countries
China
Contacts
Public ContactJiange Han
Tianjin Chest Hospital
Outcome results
None listed