Lung Squamous Carcinoma
Conditions
Interventions
Control group:Docetaxel or Gemcitabine
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
70 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged =70 years; 2. Pathological diagnosis of stage IV lung squamous carcinoma; 3. Never received any systematic chemotherapy treatment for lung squamous carcinoma; 4. ECOG PS = 2 scores; 5. Estimated life expectancy of at least 3 months; 6. Blood routine and ECG examinations are normal; liver funtion =2.5 x upper limit of normal range(ULN);; renal function =1.5 x upper limit of normal range(ULN); 7. Compliance with the study protocol, willingness to receive the treantments; 8. Ability to understand and willingness to sign IRB-approved informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with contraindications to chemotherapy, who cannot tolerate chemotherapy or refuse chemotherapy; (2) Patients with serious uncontrolled medical diseases, with dementia or any other mental illness that may hinder the patients understanding informed consent form or filling in the questionnaires; (3) Patients who are allergic to any therapeutic ingredient or with a history of hypersensitivity reaction; (4) Patients with =grade 2 peripheral neuropathy according to CTCAE V 4.03; (5) HBsAg (+) and HBV-DNA=1×103 IU/mL; when HBsAg (+) and HBV-DNA<1×103IU/mLthe patients can be inrolled in if the researcher permit; (6) HCV antibody (+) or HIV antibody (+); (7) Patients have received any other experimental drug treatment or participated in another interventional clinical trial within 30 days prior to the screening period; (8) Patients that the researcher consider not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| ORR;OS; | — |
Countries
China
Contacts
Public ContactMeng Rui
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed