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An experimental study for promoting functional collateral circulation formation in moyamoya disease patients after operation by combined treatment of vascular endothelial growth factor and Netrin-1

An experimental study for promoting functional collateral circulation formation in moyamoya disease patients after operation by combined treatment of vascular endothelial growth factor and Netrin-1

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900023049
Enrollment
Unknown
Registered
2019-05-08
Start date
2019-05-01
Completion date
Unknown
Last updated
2019-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moyamoya Disease

Interventions

Case series:No

Sponsors

Zhongnan Hospital of Wuhan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
8 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1) written informed consent had been obtained; 2) more than 8 years old and less than 60 years old; 3) cerebral digital subtraction contrast angiography (DSA) revealed severe stenosis or occlusion of the distal internal carotid or proximal middle and anterior cerebral arteries with prominent lenticulostriate 'moyamoya collaterals'; 4) received surgical revascularization; 5) having undergone preoperative and postoperative cerebral digital subtraction angiography or magnetic resonance angiography.

Exclusion criteria

Exclusion criteria: 1. has aneurysm, AVM, intracranial tumor, hydrocephalus or intracranial hemorrhage; 2. allergic to contrast medium.

Design outcomes

Primary

MeasureTime frame
endothelial progenitor cells;endotelial cells;—

Countries

China

Contacts

Public ContactZhang Jianjian

Zhongnan Hospital of Wuhan University

zj57470@126.com+86 18971352943

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026