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A randomized, double-blind placebo-controlled clinical trial protocol of Zishen Yutai Pill for in vitro fertilization-embryo transfer in patients with diminished ovarian reserve patients

A randomized, double-blind placebo-controlled clinical trial protocol of Zishen Yutai Pill for in vitro fertilization-embryo transfer in patients with diminished ovarian reserve patients

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900023042
Enrollment
Unknown
Registered
2019-05-08
Start date
2019-05-20
Completion date
Unknown
Last updated
2021-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

Sponsors

The Women and Children's Hospital of Guangdong Province
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) Patients aged 20 to 40 years; (2) Sum of AFC in both ovaries 2.0; AMH<1.1 ng/ml (Two out of three are sufficient); (3) Patients preparing to assist pregnancy by IVF-ET{ Antagonist regimen and high progesterone induced ovulation (PPOS) regimen}; (4) legal couple; (5) Patients who volunteered to participate in the trial and had signed the informed consent.

Exclusion criteria

Exclusion criteria: (1) Severe (III, IV) endometriosis; (2) Adenomyosis; (3) Untreated endometrial disease; (4) Diminished ovarian reserve due to bilateral or unilateral ovariectomy; (5) Having a medical condition that is not suitable for current assisted reproductive technology or for pregnancy; (6) Hydrosalpinx; (7) Embryo transfer failure for 3 times or more; (8) DOR patients who received other Chinese patent medicine for kidney-tonifying within 1 month (30 days) before enrollment; (9) Patients with previous ovarian resistance syndrome.

Design outcomes

Primary

MeasureTime frame
High quality embryo number rate;

Secondary

MeasureTime frame
number of oocyte retrieved;available number of embryos rate;rate of oocyte retrieval cancellation;rate of failed oocyte retrieval;non-available embryo rate;2PN cleavage number;implantation rate;clinical pregnancy rate;live birth rate;

Countries

China

Contacts

Public ContactFenghua Liu

The Women and Children's Hospital of Guangdong Province

liushine2006@163.com+86 13926478318

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026