thrombocytopenia after chemotherapy for acute leukemia
Conditions
Interventions
control group:blank
Sponsors
Anhui Provincial Hospital
Eligibility
Sex/Gender
All
Age
15 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 15-70 years, male or female; 2. Diagnosis of acute myeloid leukemia by bone marrow examination, flow cytometry and/or cytogenetic examination (include patients with acute myeloid leukemia and acute lymphoblastic leukemia with partial or complete remission); 3. PLT count <30x10^9/L during the previous cycle of chemotherapy; 4. ECOG performance status of <=2 at study entry; 5. With normal liver and renal function(BUN is less than or equal to 1.5 times of the benchmark value,Creatinine is less than or equal to 1.5 times of the benchmark value, SGPT/ALT is less than or equal to 1.5 times of the benchmark value,Bilirubin is less than or equal to 1.5 times of the benchmark value); 6. Patients without severe heart or lung dysfunctions or cerebrovascular disease; 7. No history of mental illness; 8. The estimated survival is over 12 weeks; 9. Understand and voluntarily sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with medical history of severe allergy to biological agents; 2. Patients with medical history of thrombosis; 3. Patients with thromboembolic or hemorrhagic disease; 4. Patients with M3 or M7 subtype; 5. Patients with platelet count of >300x10^9/L at the start of therapy 6. Pregnant or lactating patients, or patients with failure in use of contraception during the study period; 7. Other situations not approved by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| platelet count;lasting time of PLT<20×10e9/L; | — |
Secondary
| Measure | Time frame |
|---|---|
| quantity of platelet transfusion;Safety; | — |
Countries
China
Contacts
Public ContactZheng Changcheng
Anhui Provincial Hospital
Outcome results
None listed