Polycystic Ovary Syndrome
Conditions
Interventions
Group A:Letrozole is taken orally on the third to seventh day of the menstrual cycle
Group B:Letrozole is taken orally on the 3rd to 7th day of the menstrual cycle, and gonadotropin is intramuscularly injected on the 8th to 10th day
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. PCOS patients meeting the 2003 Rotterdam diagnostic criteria: (1) patients with rare ovulation or even no ovulation; (2) clinical symptoms or biochemical manifestations of patients show hyperandrogenemia; (3) polycystic changes of the ovary can be seen on abdominal color ultrasound (vaginal color ultrasound shows that one or both ovaries contain more than 12 follicles of 2-9mm); A diagnosis can be made if two of the above three criteria are met. 2. less than 40 years old, normal sex life, infertility course for more than 1 year; 3. hysterosalpingography indicated that the uterine morphology was normal, and at least one side of the fallopian tube was unobstructed; 4. there was no abnormal or mild oligospermia or asthenospermia in the sperm analysis results of the spouses; 5. all organs function normally, without any endocrine disorders, such as hypophysis, hyperthyroidism, etc.
Exclusion criteria
Exclusion criteria: (1) those who are known to be allergic to relevant drugs; (2) patients with mental or neurological diseases cannot actively cooperate with the experiment; (3) patients with severe cardiovascular and hepatic and renal dysfunction; (4) pregnant and lactating women; (5) have a history of abnormal diseases of uterus or uterine cavity; (6) previous exposure to teratogenic substances, radiation, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnancy rate;ovulation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| single pregnancy rate;the level of estradiol on the day of HCG injection;the level of progesterone on the day of HCG injection;the level of luteinizing hormone on the day of HCG injection;endometrial thickness on the day of HCG injection;the number of mature follicles;the rate of ectopic pregnancy;the rate of early abortion;the rate of OHSS;mutiple pregnancy rate; | — |
Countries
China
Contacts
Public ContactYi Liu
Union Hospital, Tongji Medical College,Huazhong University of Science and Technology
Outcome results
None listed