Diminished Ovarian Reserve
Conditions
Interventions
The experimental group:human umbilical cord mesenchymal stem cells
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Aged 20-45 years; 2. Diagnosis as diminished ovarian reserve, serum FSH>10IU/L, serum AMH<1.1ng/ml; 3. Ovarian volume=3cm^3, or antral follicle count = 7 in early follicular phase; 4. Willing and able to comply with the requirements of this experiment.
Exclusion criteria
Exclusion criteria: 1. Secondary ovarian insufficiency(e.g. hypothalamic); 2. Abnormal karyotypinger(e.g. turner syndrome, fragile X syndrome); 3. History of previous malignant or ovarian tumors, history of ovarian therapy; 4. Polycystic ovary syndrome; 5. Congenital uterine anomaly; 6. Severe endometriosis; 7. Autoimmune disease, history of severe familial genetic disease, etc; 8. HIV+, hepatitis B, C; 9. Allergic constitution,and human serum albumin allergy; 10. Acute or chronic infection, hematologic disease, angiocardiopathy, pulmonary disease, liver disease, nephropathy, pancreas disease; 11. Participation in another clinical study within 3 months; 12. Attending doctor considers inappropriate to take part in.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antral Follicle Count;FSH;Ovarian Volume;Vital Signs;Adverse Events; | — |
Secondary
| Measure | Time frame |
|---|---|
| E2;AMH; | — |
Countries
China
Contacts
Public ContactZhaolian Wei
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed