Hyperalgesia caused by remifentanil
Conditions
Interventions
Sufentanil group:Sufentanil 0.30 µg /kg
remifentanil:remifentanil 0.30 µg/kg/min
remifentanil and nalbuphine:remifentanil 0.30 µg /kgmin,nalbuphine0.1mg/kg
remifentanil with nalbuphi ne and parecoxib:remifentanil 0.30 µg/kg/min,nalb uphine0.05mg/kg,parecoxib 20mg
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Patients treated by laparoscopic gynecological surgery include laparoscopic hysterectomy, adnexectomy, hysteromyoma resection, the operation time within 1-3h; 2. Aged 18 to 65 years; 3. ASA I to II; 4. Body mass index (18 ~ 30kg/m2); 5. Agree to accept general anesthesia and postoperative intravenous analgesia treatment, can correctly use; 6. postoperative patient controlled intravenous analgesia pump; 7. normal liver and kidney function; 8. Patients and their families were informed and signed the informed consent for clinical research.
Exclusion criteria
Exclusion criteria: 1. A history of chronic pain or chronic use of sedatives and analgesics; 2. People with severe depression or other mental disorders; 3. History of smoking, pulmonary infection, acute or chronic tuberculosis or severe COPD; 4. Patients with systemic inflammatory response syndrome; 5. With cardiovascular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain threshold; | — |
Countries
China
Contacts
Public ContactLei Hong Yi
Outcome results
None listed