Advanced Colon Cancer
Conditions
Interventions
Sponsors
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patient with pathological diagnosis of colon cancer,tumor-node-metastasis(TNM)Stage IV colon cancer according to 8th edition of American Joint Committee on Cancer(AJCC)Staging Manual; (2) Receiving or plan to start chemotherapy of XELOX or XELIRI; (3) Aged between 18 to 80 years male and female and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. History of previous malignancy other than adequately treated in situ carcinoma of the uterine cervix or basal or squamous cell carcinoma of the skin. 2. serious heart,liver or kidney dysfunction. 3. Those who cannot take the study drug orally because of bowel obstruction and/or require for peripheral vein nutrition;or malabsorption or diseases that affect the absorption;or active peptic ulcer disease. 4. Any unstable conditions or conditions that may endanger the safety of patients and their compliance with the study; 5. Patients who received any of the following treatments during a specified period prior to the research: (1) received antibiotic treatment within 2 weeks; (2) receiving intestinal flora regulator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MD Anderson Symptom Inventory (MDASI) Score;DCR; | — |
Secondary
| Measure | Time frame |
|---|---|
| Edmonton Symptom Assessment Scale(ESAS) score;Change of Spleen Deficiency Scale Score;Change of Kidney Deficiency Scale Score;Incidence of adverse effects(AEs); | — |
Countries
China
Contacts
Public ContactYun Xu
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed