A prospective comparative study for antegrade and retrograde cerebral perfusion for cerebral protection in operation of Stanford A aortic dissection

The influence of different methods of cerebral protection on neurological complications in operation of Stanford A aortic dissection: a randomized controlled trial.

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900022941

Enrollment

Unknown

Registered

2019-05-04

Start date

2020-01-01

Completion date

Unknown

Last updated

2019-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute aortic syndrome

Interventions

antegrade cerebral perfusion:antegrade cerebral perfusion in DCHA

retrograde cerebral perfusion:retrograde cerebral perfusion in DHCA

Eligibility

Sex/Gender

All

Age

14 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. The diagnosis is Stanford A aortic dissection and the patient needs the replacement of all aortic arch. 2. Aged 14 to 65 years. 3. Sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. The history of cerebral infarction. 2. Befor surgery, the Montreal Cognitive Score is less than 26 points. 3. The ASA score is in level five. 4. The patient has skin damage on forehead so that he can not receive cerebral oxygen monitoring. 5. The time of deep hypothermic circulatory arrest is more than 40 minutes. 6. The cerebral oxygen saturation decreases more than 30%. 7. After surgery,the systolic blood pressure is less than 80 mmHg.

Design outcomes

Primary

Measure	Time frame
neurological complications;	—

Secondary

Measure	Time frame
cerebral oxygen saturation;Markers of brain injury;	—

Countries

China

Contacts

Public ContactFan Ruixin

Guangdong Provincial People’s Hospital

fanruixin@163.com+86 13825000989

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026