diffuse large B cell lymphoma
Conditions
Interventions
A:R-ICE
B:ICE
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years old, ECOG performance status of 0, 1, or 2, Life expectancy of >12 weeks; 2. All patents are diagnosed as Relapse/Refractory non-GCB diffuse large B cell lymphoma by pathology and history; 3. Adequate hematologic and hepatic-renal function: Hemoglobin >=9 g/dl, Absolute neutrophil count >=1.5*10^9/L, Platelet count >=100*10^9/L, ALT = 12 months after the last chemotherapy; 7. Ability and willingness to comply with the study protocol.
Exclusion criteria
Exclusion criteria: 1. Refuse to provide the blood sample; 2. History of severe allergic or anaphylactic reactions to any drugs including the protocol; 3. All patients of reproductive potential refuse to use adequate methods of contraception during the treatment period and until >12 months after the last chemotherapy; 4. Evidence of significant, uncontrolled concomitant diseases that could affect compliance with the protocol or interpretation of results, including significant cardiovascular disease, uncontrolled diabetes mellitus, pulmonary disease or severe hepatic and renal dysfunction; 5. Serious infections; 6. Contraindications of radiotherapy and chemotherapy; 7. History of other malignancy; 8. Mental disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR;CR;PR;SD;PD; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS;PFS;EFS; | — |
Countries
China
Contacts
Public ContactLiling Zhang
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed