endometrial cancer
Conditions
Interventions
experimental group:Triprimab, 240 mg intravenously, 4 times every 3 weeks. At the same time, Yining, 160 mg, once a day
Control group:Yining, oral 160 mg, once a day
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) Early stage endometrial cancer patients (tumor is confined to the endometrium, endometrioid carcinoma, G1-2); 2) The patient has a fertility request or is required to retain the uterus due to other factors; 3) Obtain informed consent from patients and are willing to receive relevant treatment and follow-up; 4) Aged 18 to 45 years old; 5) ECOG score = 1; 6) Normal blood test (WBC=4*10^9/L, HB=10g/L, PLT=100*10^9/L); 7) Normal liver and kidney function.
Exclusion criteria
Exclusion criteria: 1) The patient has been or is undergoing immunological checkpoint inhibitor treatment; 2) The patient needs or requires treatment with other anti-tumor drugs (such as chemotherapy drugs) other than progesterone during the test; 3) The patient has a history of allergies to immunological checkpoint inhibitors; 4) The patient has a tendency to easily bleed; 5) Patients with abnormal blood or liver and kidney function; 6) The patient has a history of cardiovascular disease, including severe hypertension, severe arrhythmia, and history of myocardial infarction; 7) The patient has a history of hepatitis B or hepatitis C infection with a detectable viral load; 8) Severe obstructive pulmonary disease; 9) Patients with autoimmune diseases; 10) Those who need corticosteroids or other immunosuppressive agents every day due to other diseases; 11) Active tuberculosis patients; 12) History of other malignant tumors; 13) Patients with acute infection; 14) Vaccinated patients within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pathologic examination of endometrial; | — |
Countries
China
Contacts
Public ContactXiaoping Wan
Shanghai First Maternity and Infant Hospital
Outcome results
None listed