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Effect of a very early molibization on the recovery of walking function after ischemic stroke and expression of BDNF

Effect of a very early molibization on the recovery of walking function after ischemic stroke and expression of BDNF

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900022872
Enrollment
Unknown
Registered
2019-04-28
Start date
2015-12-01
Completion date
Unknown
Last updated
2019-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemic stroke recovery

Interventions

experimental group:Patients randomized to the experimental group began rehabilitation as soon as practical after randomization, with the goal of first rehabilitation within 24–48 hours of stroke onset
Control group :the control group received standard care from ward therapists and nursing staff including positioning, range of motion exercises, bed mobilization, physiotherapy, and education of patie

Sponsors

The First Affiliated Hospital of Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Aged 18–80 years; admitted to the hospital within 48 hours of onset, in line with the diagnostic criteria adopted by the Fourth National Cerebrovascular Conference, and diagnosis confirmed by CT or MRI; stable vital signs: systolic blood pressure 92%;4 weakness in the lower limbs and a National Institutes of Health Stroke Scale (NIHSS) score17 of =1 on item VI; no contraindications to mobilization within 48 hours of stroke onset (based on the medical teams clinical judgment and exclusion criteria); the ability and willingness to provide informed consent.

Exclusion criteria

Exclusion criteria: Premorbid modified Rankin Scale (mRS) score18 >3 and/or lower limb fracture that prevented mobilization within 3 months; other progressive neurological diseases such as dementia, Parkinsons disease, epilepsy, tumor, or serious cardiovascular disease, pulmonary infection, uremia, or malignant tumor; severe cognitive impairment, aphasia, or visual or hearing impairment that precluded performance of the evaluation.

Design outcomes

Primary

MeasureTime frame
the number of days to walking 50 m;the change in lower extremity motor control from admission to 4 weeks, assessed by the Fugl-Meyer Assessment (FMA);

Secondary

MeasureTime frame
change in balance assessed by the Berg Balance Scale score (BBS);performance of activities of daily living;mRS was used to assess the overall function and prognosis;

Countries

China

Contacts

Public ContactWenxiu Wu

The First Affiliated Hospital of Wenzhou Medical University

lisa787878@163.com+86 13905873965

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026