Sarcopenia in COPD
Conditions
Interventions
Case series:none
Sponsors
Fudan University Huadong Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. sign a written informed consent form; 2. Aged 40 to 70 years old; 3. To be able to complete exercise, 6-minute walk test and pulmonary function test; 4. Chronic obstructive pulmonary diagnosis should be based on the American Chest Association (ATS)/European Respiratory Society (ERS) 2016 GOLD definition. Subjects with a history of chronic obstructive pulmonary disease, pulmonary function FEV1/FVC after bronchodilator administration The ratio <0.70, currently smoking or former smokers, has a history of smoking for more than 10 pack years; 5. Definition of COPD stable period: Subjects with a history of chronic obstructive pulmonary disease are known to meet the following conditions: In the past 2 years, they have been admitted to hospital for 2 times due to acute exacerbations, and the condition is stable in the past 1 month without sputum trait changes. Due to respiratory symptoms, it is necessary to change the history of long-term use of drugs; 6. according to the investigator's judgment, the subject is willing and able to adjust the current treatment of chronic obstructive pulmonary disease according to the program requirements; 7. Patients have good compliance: Subjects must be willing to complete all visit assessments at the research center as required by the protocol.
Exclusion criteria
Exclusion criteria: 1. A significant disease or condition other than COPD, which, at the discretion of the investigator, results in a subject who is at risk for participating in the study or who has an influence on the outcome of the study and the ability of the subject to participate in the study; 2. cardiac function NYHA grade IV, or recent uncontrolled activity after chest tightness and angina; 3. those who are expected to have a life cycle 55 mmHg (1 mmHg=0.133 kPa) in a quiet state; 9. There are other serious diseases such as heart, liver, kidney, nervous system, endocrine, etc., which may not adhere to the completion of the study, or may affect the research process and / or results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mini nutritional assessment;Grip strength;ASMI;TNFa;il-6; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary function;BMI;COPD assessment test; | — |
Countries
China
Contacts
Public ContactTing Zhao
Outcome results
None listed