Gastric cancer and precancerous gastric lesions
Conditions
Interventions
Intervention group:H.pylori eradication therapy
Placebo group:placebo
H.pylori negative follow-up group:follow-up
Sponsors
Peking University Cancer Hospital & Institute, Beijing Institute for Cancer Research
Eligibility
Sex/Gender
All
Age
40 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Male or non-pregnant, non-nursing female participants will be eligible. 2. The age limits are 40–69 years. 3. Subjects must sign an informed consent form (ICF) and receive a questionnaire interview.
Exclusion criteria
Exclusion criteria: 1. Peptic ulcers; 2. Being treated for serious medical condition which could hinder participation; 3. Undergoing active treatment for cancer; 4. Current or previous antibiotic therapy for H. pylori infection; 5. History of congestive heart failure; 6. Respiratory failure; 7. Stroke, seizures, dementia; 8. Psychiatric illness; 9. Alcoholism or drug abuse; 10. Presence of a contraindication to the use of metronidazole, tetracycline or omeprazole; 11. Family history of GC in a first degree relative; 12. History of severe impaired renal function (GFR < 50%); 13. Contraindication for biopsy sampling (e.g. comprised plasmatic or cellular blood clotting).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H.pylori infection status;pathology diagnosis of gastric biopsy; | — |
Secondary
| Measure | Time frame |
|---|---|
| biomarkers for gastric cancer; | — |
Countries
China
Contacts
Public ContactKaifeng Pan
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing Institute for Cancer Research
Outcome results
None listed