Postoperative Gastrointestinal Symptoms After Laparoscopic Sleeve Gastrectomy
Conditions
Interventions
Group 1:Synbiotics (Probiotics + Prebiotics)
Group 2:Synbiotics (Probiotics + Prebiotics)
Group 3:None
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Adults who are between 18 and 65 years old, with 35 < BMI <45 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Get infected with hepatitis virus (hepatitis B and C virus), suspected of fatty liver that is secondary to hepatotoxic drugs, excessive drinking (male=30 g/day, female=20 g/day); 2. Use antibiotics or probiotics in the past 3 months, or use other probiotics & prebiotics and use >3 days of antibiotics during the study period, or have previously undergone bariatric surgery; 3. Diabetic patients treated with anti-diabetic drugs should be excluded except those treated with metformin at a stable dose for at least 6 months; 4. Suffering from serious heart, liver, lung, kidney diseases or serious organic diseases; 5. Any time of the 3 times of sampling is unavailable or any subject misses one sampling, and then this subject will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal symptoms (Bristol stool form scale; Post-operative nausea and vomiting intensity scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbiota Composition;weight loss;excess weight loss percentage; | — |
Countries
China
Contacts
Public ContactMeng Hua
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Outcome results
None listed