Skip to content

A Prospective, Single/ Multiple Center, Single-Arm Study for Chimeric Translational Molecules of Neoantigen Reactive T Cells (cnTs) Combined with Personalized Neoantigen-Primed DC Cancer cell (neoDC-Vx) in the Treatment of Advanced Refractory Solid Tumors

A Prospective, Single/ Multiple Center, Single-Arm Study for Chimeric Translational Molecules of Neoantigen Reactive T Cells (cnTs) Combined with Personalized Neoantigen-Primed DC Cancer cell (neoDC-Vx) in the Treatment of Advanced Refractory Solid Tumors

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900022835
Enrollment
Unknown
Registered
2019-04-27
Start date
2019-05-01
Completion date
Unknown
Last updated
2019-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Advanced refractory solid tumors

Interventions

Experience group :Immunotherapy

Sponsors

The Affiliated Hospital of Southwest Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) aged 18-75 years for cancer patients, regardless of gender; 2) patients diagnosed with cancer, sarcoma, lymphoma and other malignant tumors by histological biopsy; 3) patients undergoing first - and second-line (at least 2 schemes and above) treatment and efficacy evaluation; 4) patients who are unable to tolerate or unwilling to receive first - and second-line chemotherapy; 5) patients with expected survival of more than 2 months; 6) no other immunotherapy drugs were used within 4 weeks before participating in this study; 7) the patient agrees to participate in the test and has signed the informed consent.

Exclusion criteria

Exclusion criteria: 1) participated in other clinical trials within 4 weeks before the start of this study; 2) patients who are taking chemotherapy or taking immunosuppressive agents within 2 weeks before the start of this study; 3) there were uncontrollable severe cardiac toxicity, allergic and other side effects during anti-tumor therapy; 4) there is no clinical evidence to suggest that patients with severe or uncontrolled systemic disease, such as disease, researchers believe that patients are not suitable for to participate in the test including severe high blood pressure, heart disease, such as: heart disease (namely II and II above cardiac function); 5) there are active infections, such as hepatitis b, hepatitis c, tuberculosis, AIDS, etc., which are considered inappropriate for the researchers to participate in the clinical trial; 6) the ecg results indicated obvious abnormalities, which was deemed inappropriate for the researchers to participate in the clinical experiment;Brain disease, abnormal judgment; 7) pregnant or lactating women; 8) it was determined by the researchers that the patients who were not suitable for this study were not suitable. If any of the above answers is "yes", this subject cannot participate.

Design outcomes

Primary

MeasureTime frame
efficient;Survival rate;Adverse reaction;

Countries

China

Contacts

Public ContactWen Qinglian

Department of Oncology, Affiliated Hospital of Southwest Medical University

wql73115@163.com+86 13518388130

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026