gastroesophageal reflux disease
Conditions
Interventions
Patient Group:MCE test + 24-hour esophageal PH-impedance monitoring + esophageal manometry
Control Group:MCE test + 24-hour esophageal PH-impedance monitoring + esophageal manometry
Sponsors
Department of Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) aged 18 to 75 years; 2) patients with typical symptoms of gastroesophageal reflux disease: heartburn, reflux and chest pain, symptoms lasting for more than 3 months, at least 3 times a week;Or their gender and age match healthy people. 3) sign the informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1) history of thoracic, esophageal and gastric surgery. 2) history of heart disease. 3) esophageal dyskinesia: scleroderma, diabetes, autonomic or peripheral neuropathy, and myopathy. 4) potential mental illness. Contraindications with MCE examination, include: (1) no conditions for operation or refusal of any abdominal operation (once the capsule remains, it cannot be removed surgically). (2) in vivo with pacemakers, but pacemakers for the new MRI compatibility of products; (3) implant electronic cochlear implant, magnetic metal drug infusion pump, nerve stimulator and other electronic devices and magnetic metal stuff; (4) pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reflux barrier classification under the MCE test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum area of cardia (of stomach) when commit water swallow;Maximum and minimum area of cardia (of stomach) when commit water swallow when commit deap breath;Maximum area of cardia (of stomach) after abdominal pressure belt is used;Effect of PPI treatment.; | — |
Countries
China
Contacts
Public ContactYinglian Xiao
Department of Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed