chronic renal failure
Conditions
Interventions
Experimental Group:Combined therapy of UMM-130 hemoperfutor and high flux hemodialysis
Control Group:Combined therapy of HA 130 hemoperfutor and high flux hemodialysis
Control Group :High flux hemodialysis
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Patients diagnosed as chronic renal failure; 2) Gender is not limited, the age ranges from 18 to 75 years (including 18 and 75 years old); 3) Hemodialysis was performed regularly, 2-3 times a week, 3-5 hours each time, and the blood flow was 200 ml/min-250 ml/min. 4) Voluntary signature of "informed consent".
Exclusion criteria
Exclusion criteria: 1) Patients who use peritoneal dialysis or central venous catheter at the same time; 2) Shock or systolic blood pressure below 90 mmHg; 3) Those with bleeding or serious bleeding tendency; 4) Leukocyte count 190 cm or height 33 kg/m2), excessive weight loss (BMI < 18.5 kg/m2); 13) The clinical trials of dialyzers, dialysates and perfumers have been or are taking part in within two weeks from the screening date. 14) Those who have poor compliance and can not be treated according to the plan; 15) Researchers believe that patients cannot participate in any other situation of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction rate of indolephenol sulfate;Reduction rate of p-cresol sulfate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction rate of ß2-microglobulin;Reduction rate of serum creatinine;Reduction rate of blood urea;Ultrafiltration rate; | — |
Countries
China
Contacts
Public ContactXiaoqiang Ding
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed