traumatic brain injury
Conditions
Interventions
Experimental group:25 mg of NBP administered intravenously, twice daily, 10 days + conventional treatment
Control Group:conventional treatment
Sponsors
Changzhou Wujin People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: History of brain injury; aged 18 to 70 years (inclusive); admission within the first 24 hours after injury; isolated TBI with subarachnoid hemorrhage confirmed by head CT or MRI examination; symptoms such as headache, nausea, vomiting, disturbance of consciousness, or meningeal irritation.
Exclusion criteria
Exclusion criteria: A nonsurvivable brain injury; other primary diagnosis such as subdural hematoma, epidural hematoma or contusion; polytrauma, defined as greater than 1 nonhead body region with Abbreviated Injury Severity (AIS) score greater than 3; pregnant or lactating women; history of severe cardiac and pulmonary diseases; severe mental retardation or prior severe brain injury; previous enrollment in any other clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral blood volume;Cerebral blood flow;Mean transmit time;Velocity of middle cerebral artery;IL-1ß level of blood sample;IL-6 level of blood sample;TNFa level of blood sample;IL-1ß level of CSF;IL-6 level of CSF;TNFa level of CSF; | — |
Countries
China
Contacts
Public ContactJin Peng
Changzhou Wujin People's Hospital
Outcome results
None listed