Psoriasis vulgaris
Conditions
Interventions
Healthy control group:No intervention
Sponsors
Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients inclusion criteria: 1.Complies with the diagnostic criteria for psoriasis vulgaris in dermatovenerology 8th Edition; 2. Complies with the diagnostic criteria for blood-heat syndrome in Guidelines for the Clinical Research of Chinese Medicine New Drugs and New Dermatology of Traditional Chinese Medicine; 3. Aged 18 to 70 years; 4. Patients signed informed consent; 5. Recurrent psoriasis patients must belong to the types of recurrenceIV, V, VI. Health volunteers inclusion criteria: 1. Aged 18 to 65 years; 2. No family history of psoriasis; 3. People who used corticosteroids or immune agents within a month. 4. People without serious systemic diseases, tumors, immunodeficiency or mental disorders.
Exclusion criteria
Exclusion criteria: 1. Psoriasis with other skin diseases; 2. Combined with cardiovascular and cerebrovascular diseases, liver, kidney and hematopoietic system diseases; other severe systemic chronic wasting diseases, and mental diseases; 3. Patients who have hyperlipidemia, vitamin A too high, women of childbearing age; 4. Received systemic glucocorticoid, retinoic acid and methotrexate drugs within a month, use glucocorticoid drugs in external for nearly 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psoriasis area and severity index;Itching degree score;The quantities and distribution of Th1, Th2, Th17, Treg, Th22 and Th9 cells in peripheral blood;Genes and proteins levels of transcription factors(T-bet?GATA3?ROR?t?Foxp3);Detection and screening of downstream cytokines(IFN-??IL-4?IL-17A?IL-17F?IL-22?TGF-ß?IL-10 ?IL- 9); | — |
Countries
China
Contacts
Public ContactHao Pingsheng
Chengdu University of Traditional Chinese Medicine
Outcome results
None listed