Major depressive disorder
Conditions
Interventions
Group 1:Single 500mg ethosuximide treatment
Group 2:Single 1000mg ethosuximide treatment
Group 3:Single 1500mg ethosuximide treatment
Group 4:Single placebo treatment
Group 5:Repeated 1500mg ethosuximide treatment
Sponsors
Chaohu Hospital affiliated to Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Responding to the diagnosis of Major Depressive Disorder according to DSM IV; 2. Introducing a single depressive episode or recurrent unipolar; 3. Absence of treatment with antidepressant during the last 6 months; 4. Informed consent been signed.
Exclusion criteria
Exclusion criteria: 1. Lifetime history of psychotic features, diagnosis of schizophrenia or any other psychotic disorder, or diagnosis of bipolar disorder; 2. Patients judged clinically to be at serious and imminent suicidal or homicidal risk; 3. Women who are either pregnant or nursing; 4. Serious, unstable medical illnesses including hepatic, renal impairment, respiratory (including obstructive sleep apnea, or history of difficulty with airway management during previous anesthetics), cardiovascular (including ischemic heart disease and uncontrolled hypertension), endocrinologic, neurologic (including history of severe head injury), immunologic, or hematologic disease; 5. Clinically significant abnormal findings of laboratory parameters, physical examination, or ECG; 6. Patients who have a positive urine toxicology for illicit substances at screening and within 24 hours of the infusion; 7. Previous recreational use of ketamine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD;MADRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS;HAMA; | — |
Countries
China
Contacts
Public ContactKai Zhang
Chaohu Hospital affiliated to Anhui Medical University
Outcome results
None listed