Vascular cognitive impairment
Conditions
Interventions
None listed
Sponsors
Jilin University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Aged 50-80 years old; (2) Can cooperate with the completion of the relevant inspection in this study; (3) Informed consent and signature of informed consent for this study. The criteria for the admission of transient ischemic attack were as follows: (1) The onset is rapid, which is short-term, reversible and local cerebral blood circulation disorder, and can recur; (2) The main symptoms were internal carotid artery (movement, sensory impairment, loss of monocular vision, aphasia, etc.) and vertebral-basilar artery (multiple symptoms and signs, such as diplopia, vertigo, dysphagia, disappearance of bilateral vision, hemianopia, etc.). The onset time was usually several minutes to one hour, and disappeared within 24 hours; (3) Irresponsible lesions in imaging; Entry criteria for mild ischemic stroke: (1) Stroke-like onset; (2) Focal neurological deficits (such as pure motor hemiplegia, pure sensory stroke, mixed motor-sensory stroke, dysarthria-clumsiness syndrome, ataxia hemiplegia, dysarthria, drinking cough, involuntary movement, pseudobulbar palsy, cognitive decline, etc.); NIHSS score 50%).
Exclusion criteria
Exclusion criteria: (1) Drugs affecting cognitive function were used within 2 weeks before screening; (2) There are other central nervous system conditions leading to cognitive impairment, such as metabolic encephalopathy, Parkinson's syndrome, Huntington's disease, subdural hematoma, normal intracranial pressure hydrocephalus, brain tumors, brain trauma, etc.; (3) There are other systemic conditions leading to cognitive impairment, such as hypothyroidism, vitamin B12 or folic acid deficiency, nicotinic acid deficiency, severe anemia, liver insufficiency, renal insufficiency, hyponatremia, hypocalcemia, neurosyphilis, HIV infection, alcohol and drug abuse; (4) Cognitive impairment caused by mental disorders such as depression and schizophrenia; (5) those who refuse to take blood or who are contraindicated by nuclear magnetic resonance (NMR); (6) patients with serious heart, liver and kidney diseases; (7) Visual impairment, aphasia and deafness are not enough to perform tasks and scale operation; (8) History of stroke and severe sequelae; (9) suffering from illness that can not cooperate with the completion of cognitive examination; (10) Those who refuse to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;proteomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Medical Imaging;Laboratory Examinations; | — |
Countries
China
Contacts
Public ContactLi Sun
Department of Neurology of the First Hospital of Jilin University
Outcome results
None listed