Osteosarcoma and soft tissue sarcoma
Conditions
Interventions
A:The patients distributed in group A was treated with rhTPO immediately at a dose of 300 U.d-1.kg-1, ih.
B:The patients distributed in group B continued to observe and check blood every other day. When platelets were found to be less than 75*109/L, rhTPO was administered subcutaneously at a dose of 300 U
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Histopathology diagnosed with osteosarcoma or soft tissue sarcoma, and suitable for doxorubicin + isocyclophosphamide treatment; 2. Aged 10 to 70 years, expected survival time >6 months; ECOG:0-1,and amputees could be relaxed to 2 points; 3. Normal bone marrow hematopoietic function(no blood transfusion, no G-CSF, no drug correction within 14 days before screening): 1) ANC=1.5×10^9/L, PLT=100×10^9/L, Hb=90g/L; 2) Cr= 1.5 ULN or CCR= 60 ml/min, TBIL= 1.5 ULN, ALT/AST= 2.5 ULN ( liver metastasis subjects can be relaxed to = 5 ULN); 3) INR= 1.5, PT= 1.5 ULN, APTT = 1.5 ULN; 4) urinary protein 2+), 24-hour urinary protein quantitative display must be (< 1 g); 4. Cardiac function was normal by ECG and echocardiography; 5. Before the start of the study, all patients have been fully understood the research and the must sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Heart function: NYHA score = 2, or LVEF < 50%; 2. Suffering from mental or neurological disorders, can not cooperate; 3. Known allergies to research drugs or any of their excipients; 4. Pregnant or lactating women, or those who plan to become pregnant during the study or within one year after the last use of the drug; 5. The investigator believes that the patient's condition is not suitable for this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of grade III/IV thrombocytopenia; | — |
Countries
China
Contacts
Public ContactJing Chen
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed