Acute Myocardial Infarction
Conditions
Interventions
experimental group 1:intracoronary injection of rh-proUK+ thrombus aspiration+PCI
experimental group 2: thrombus aspiration+intracoronary injection of rh-proUK+PCI
control group:thrombus aspiration+PCI
Sponsors
Hu'nan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.The patient was diagnosed as ST-segment elevation myocardial infarction and symptoms onset less than 12h; 2. Aged 18 to 75 yeas old; 3. Coronary angiography showed the TIMI thrombus grade=2.
Exclusion criteria
Exclusion criteria: (1) Patients with rescue PCI who have undergone intravenous thrombolysis; (2) History of intracranial hemorrhage; (3) Ischemic stroke within 3 months; (4) Suspicious aortic dissection; (5) Active bleeding (including menstruation); (6) Severe head or face injuries within 3 months; (7) Severe or uncontrolled high blood pressure (SBP>180mmHg or DBP>110mmHg); (8) Severe trauma, major surgery or unoppressible vascular bleeding within 3 weeks; (9) Malignant tumors or patients with life expectancy less than half a year; (10) Severe liver or kidney dysfunction; (11) History of hematologic diseases or oral warfarin recently; (12) Pregnant women, lactating women or women who may become pregnant; (13) It is known that there is a contraindication to the study drug or contrast agent; (14) Patients who have undergone coronary artery bypass grafting; (15) Patients have participated in other clinical studies at the same time; (16) Thrombus aspiration catheter cannot pass through the lesion of the criminal vessel.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corrected TIMI frame count; | — |
Secondary
| Measure | Time frame |
|---|---|
| TIMI blood flow grading;TIMI myocardial perfusion grade;Myocardial Blush Grades;TIMI thrombosis grading;ST-segment resolution in 1h after PCI; | — |
Countries
China
Contacts
Public ContactPan Hongwei
Hu'nan Provincial People's Hospital
Outcome results
None listed