Effects of probiotics on social behavior, serum biochemical parameters, and intestinal/oral flora in children with autism spectrum disorders and Prader-Willi Syndrome

Conditions

Autism spectrum disorder and Prader-Willi Syndrome

Kevin Liu, Xuejun Kong

Probiotics and Antimicrobial Proteins2022-04-263 citations

The Effects of Limosilactobacillus reuteri LR-99 Supplementation on Body Mass Index, Social Communication, Fine Motor Function, and Gut Microbiome Composition in Individuals with Prader-Willi Syndrome: a Randomized Double-Blinded Placebo-Controlled Trial.

Kong XJ, Liu K, Zhuang P, Tian R, Liu S, Clairmont C, Lin X, Sherman H, Zhu J, Wang Y, Fong M, Li A, Wang BK, Wang J, Yu Z, Shen C, Cui X, Cao H, Du T, Wan G, Cao X.

2021-06-1110 citations

10.1007/s12602-021-09800-9

Interventions

experimental group:phase I: probiotics

phase II: placebo

control group:phase I: placebo

phase II: probiotics

Eligibility

Sex/Gender

All

Age

6 Years to 22 Years

Inclusion criteria

Inclusion criteria: 1.1 All participants shall meet the following inclusion criteria: 1.1.1 Aged 2-10 years; 1.1.2 Autism was diagnosed with The Fifth Edition of The Diagnostic and Statistical Manual of Mental Disorders (dsm-5), The ADOS and/or The adi-r; 1.1.3 Gastrointestinal symptoms, such as diarrhea, constipation and other abdominal discomfort; 1.1.4 IQ is 80 or above.

Exclusion criteria

Exclusion criteria: 1.2 Exclusion criteria: 1.2.1 Pregnant women (before or during the study); 1.2.2 A history of other neurological and/or psychiatric disorders, such as seizures, schizophrenia, or substance abuse; 1.2.3 Current use of psychotropic drugs; 1.2.4 History of use of oxytocin and probiotics.

Design outcomes

Primary

Measure	Time frame
T lymphocyte subset;serum biochemical parameters;Cytokine;Oral/intestinal microflora sequencing;Sociological behavior score;	—

Countries

China

Contacts

Public ContactXia Cao

The Second Affiliated Hospital of Kunming Medical Univ

1244815508@qq.com+86 13518769225

Outcome results

None listed