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A randomized, double-blind, parallel controlled clinical trial for Qilu Buxue Granule in the prevention and treatment of leukopenia after chemotherapy for lung adenocarcinoma

A randomized, double-blind, parallel controlled clinical trial for Qilu Buxue Granule in the prevention and treatment of leukopenia after chemotherapy for lung adenocarcinoma

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900022643
Enrollment
Unknown
Registered
2019-04-19
Start date
2019-04-19
Completion date
Unknown
Last updated
2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adenocarcinoma of lung

Interventions

experimental group:Chemotherapy + Qilu Buxue Granule
control group:Chemotherapy +placebo

Sponsors

Chongqing Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. There is no bone marrow suppression in patients with lung adenocarcinoma, and the researchers have determined that the chemotherapy regimen is acceptable. 2. Those who can accept platinum-containing regimens (NP, GP, AP regimens) are expected to be able to observe two cycles of chemotherapy. 3. Patients receiving the platinum-containing regimen include: as a chemotherapy regimen for patients with advanced adenocarcinoma, post-operative adjuvant chemotherapy for patients with completely resected stage II-III adenocarcinoma, and preoperative short-term neoadjuvant chemotherapy for patients with resectable stage III adenocarcinoma. 4. Peripheral white blood cells (> 4.0x10^9/L), neutrophils (> 2.0x10^9/L) and ZPS (ECOG) scores (< 2) before chemotherapy. 5. The patient's vital signs were stable before chemotherapy, the laboratory examination indexes were stable, the estimated survival time was more than 3 months. 6. Aged 18-75 years; 7. Volunteer to sign informed consent.

Exclusion criteria

Exclusion criteria: 1. With a history of bone marrow depression of degree III-IV in the past; 2. Patients receiving concurrent radiotherapy or those unable to accept the above-mentioned chemotherapy regimen due to disease progression; 3. Patients with liver cirrhosis, hypersplenism and hematological diseases; 4. Patients with with obvious infection; 5. Weight loss of more than 15% in the last month; 6. Allergic constitution, allergic to any known ingredient in the research drug; 7. Those who have participated in other clinical trials in the past one month.

Design outcomes

Primary

MeasureTime frame
white blood cell;Neutrophils;

Secondary

MeasureTime frame
Platelet;Red blood cell;Hemoglobin;TCM Symptom Score;

Countries

China

Contacts

Public ContactZhang Ying
zhangying790318@163.com+86 13983173506

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026