Lung cancer
Conditions
Interventions
Gold Standard:The mean value of the interpretations of PD-L1 (22C3) from 3 pathologists with more than 5 years of experience in clinical pathological diagnosis, based on the digital slides.
Index test:The 
Pannoramic 
(3DHISTECH) 
be 
used 
to 
PD-L1 
(22C3) 
IHC 
slides. 
Then, 
tumor 
Sponsors
Daping Hospital, Army Medical University, PLA
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: We enrolled PD-L1 (antibody clonal:22C3) staining slides by immunohistochemical (IHC) of lung adenocarcinoma resected specimens from the department of pathology, Daping hospital after October 01, 2018. The tumor proportion score (TPS) of positive expression of PD-L1 was determined according to the following criteria: TPS refers to the percentage of tumor cells stained with partial or complete membrane (1+) in all tumor cells (negative and positive) present in the sample. Only visible and clear membrane staining of tumor cells, partial or complete cell membrane staining score (1+) will be scored; stained immune cells and cytoplasmic staining cells were not involved in the scoring.
Exclusion criteria
Exclusion criteria: Core needle and bronchial biopsy samples, malignant pleural effusion cell blocks. Lung squamous cell carcinoma, large cell carcinoma, small cell carcinoma and other non-adenocarcinoma samples. Patients who had either received chemotherapy, radiotherapy or targeted therapy before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PD-L1 positive tumor ratio score; | — |
Countries
China
Contacts
Public ContactHua-liang Xiao
Daping Hospital, Army Medical University, PLA
Outcome results
None listed