lung cancer
Conditions
Interventions
High expression group of HK3 in lung cancer:RQ-PCR
Low expression group of HK3 in lung cancer:RQ-PCR
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Histologically confirmed squamous or non-squamous histological features of stage IV or recurrent NSCLC, and systemic anticancer therapies (including EGFR, ALK inhibitors) have not previously been the primary treatment for advanced or metastatic disease. 2. Measured lesions with CT or MRI examination according to the RECIST 1.1 standard. 3. Immunohistochemistry confirmed positive expression of PD-L1. 4. No EGFR mutation, ALK ectopic. 5. Subjects with CNS metastases, even if they are asymptomatic, require treatment before they can be included.
Exclusion criteria
Exclusion criteria: 1. People have other malignant tumor; 2. Refused to sign the informed consent; 3. The researchers believe that the other condition to lead to that they dont fit into the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hexokinase 3;Over all survival (OS); Progression-free survival (PFS);Objective Response Rate (ORR); | — |
Countries
China
Contacts
Public ContactLiu Jun
Outcome results
None listed