Major Dpressive Disorder and Bipolar disorder
Conditions
Interventions
Normal group:Nil
Bipolar depression group:Nil
Unipolar depression group:Nil
Sponsors
Yuquan Hospital, Tsinghua University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: In the two experimental groups, 30 patients were included in the bipolar depression group or the bipolar depression group, and 30 healthy controls will be enrolled. The specific entry criteria are as follows: 1. consistent with DSM-5 in the treatment of major depressive disorder (ie, unipolar depressive disorder) or bipolar disorder is currently the diagnostic criteria for depressive episodes; 2. to ensure that all patients fully understand the content of the participating experiments, volunteer to participate in the study, And signed informed consent; 3. Be able to perform clinical interviews, understand the scale content and complete. Bipolar depression (bipolar affective disorder group) enrollment criteria: 1) Comply with the diagnostic criteria for bipolar (type I and type II) disorders of major depressive episodes in the Diagnostic and Statistical Manual of Mental Disorders, edited by the American Psychiatric Association, 5th Edition (DSM-V); 2) Aged 18-60 years old; 3) With education background of junior high school or higher; 4) There has been at least one manic or hypomanic episode or mixed episode; 5) 24 items of Hamilton Depression Scale total score = 21 points; 6) The first patient has not taken the drug during the measurement period; 7) All subjects are right-handed; Participants were enrolled by two deputy chief physicians through observation, medical history collection, and diagnosis of bipolar depression. The scale was assessed by two deputy chief physicians using a combination of observation and conversation. Approved by the school ethics committee, all subjects signed informed consent before enrollment. Single-phase depression (hyper-depressive disorder) enrollment criteria: 1) Comply with the Diagnostic and Statistical Manual of Mental Disorders, edited by the American Psychiatric Association, 5th Edition (DSM-V) for the diagnosis of major depressive disorder; 2) Aged 18-60 years old; 3) The level of education above junior high school; 4) Chinese version of the mood disorder questionnaire (MDQ) screening negative; 5) 24 items of Hamilton Depression Scale total score = 21 points; 6) The first patient has not taken the drug during the measurement period; 7) All subjects are right-handed. Participants will be enrolled by two deputy chief physicians through observation, medical history collection, and diagnosis of unipolar depression. The scale was assessed by two deputy chief physicians using a combination of observation and conversation. Approved by the school ethics committee, all subjects signed informed consent before enrollment. Normal control group inclusion criteria: Two deputy directors of the doctors conducted an assessment to rule out psychiatric illnesses and past mental illnesses; (1) Aged 18-60 years old; (2) The educational level of junior high school or above; (3) All subjects are right-handed.
Exclusion criteria
Exclusion criteria: Bipolar depression exclusion criteria: 1. due to serious illness can not complete the assessment; 2. combined with schizophrenia and its spectrum disorders, various personality disorders, anxiety disorders, obsessive-compulsive disorders and psychoactive substances use or dependence and other mental illness. Single-phase depression exclusion criteria: 1) History of other mental illnesses other than bipolar disorder; 2) Combine brain organic diseases and history of brain trauma; 3) History of substance/drug-induced mental disorders and serious somatic diseases; 4) Bipolar disorder rapid circulation type 5) Pregnant and lactating women. 6) Receiving electroconvulsive therapy (ECT) in the past 3 months; Normal control exclusion criteria: 1) History of other mental illnesses other than major depressive disorder; 2) Combine brain organic diseases and history of brain trauma; 3) History of substance/drug-induced mental disorders and serious somatic diseases; 4) Pregnant and lactating women. 5) Receiving electroconvulsive therapy (ECT) in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean oxy-Hb changes; | — |
Secondary
| Measure | Time frame |
|---|---|
| VFT task performence; | — |
Countries
China
Contacts
Public ContactKun Feng
Yuquan hospital, Tsinghua University
Outcome results
None listed