Neuromuscular block for surgical anesthesia in children
Conditions
Interventions
M Group:Rocuronium and sugammadex for moderate neuromuscular block in laparoscopic surgery in children under 3 years old
D Group:Rocuronium and sugammadex for deep neuromuscular block in laparoscopic surgery in children under 3 years old
Sponsors
Guangzhou Women and Children's Medical Center
Eligibility
Sex/Gender
All
Age
0.3 Years to 3 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing endotracheal intubation or laryngeal mask ventilation during day surgery; 2. Children between the ages of 3 months and 3 years old; 3. intraoperative use of a single dose of rocuronium, postoperative use of sugammadex to reverse the neuromuscular block of rocuronium; 4. ASA grade I-II.
Exclusion criteria
Exclusion criteria: (1) known or potential neuromuscular disorders; (2) using a drug that interacts with rocuronium or a drug that affects nerve-muscle conduction; (3) malnutrition or excessive obesity before surgery; (4) obvious heart, lung disease or abnormal liver and kidney function; (5) Patients with a family history of allergies or malignant hyperthermia for general anesthesia; (6) Patients with obvious cardiopulmonary, hematological, endocrine or metabolic gastrointestinal diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle relaxant effect;TOFr recovery time;Rocuronium plasma concentration;sugammadex plasma concentration;Vital signs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain;surgical condition;Postoperative adverse events; | — |
Contacts
Public ContactLibilian
Guangzhou Women and Children Medical Center
Outcome results
None listed