non-motor symptoms of Parkinson’s disease
Conditions
Interventions
entacapone group:Patients in the entacapone group will be administered entacapone (Novartis
import drug registration certificate number: H20160680), 10 times per day, 200 mg each time, for 3 weeks.
pramipexole group:Patients in the pramipexole group will be administered pramipexole (Boehringer-Ingelheim
import drug registration certificate number: 20140918) , 3 times per day, 1 mg each time, for 3 weeks.
Sponsors
Geriatric Hospital of Hainan
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1 Accordance with British Brain Bank Diagnostic Criteria for idiopathic Parkinson's Disease; 2 Record daily activities correctly; 3 Patient age 40 to 75 years, irrespective of sex; 4 Provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1 History of drug abuse; 2 Schizophrenia or severe cognitive impairment; 3 Epilepsy; 4 Severe metabolic dysfunction such as diabetes mellitus; 5 Malignant tumor; 6 Participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement rate of non-motor symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum soluble interleukin-2 receptor levels;Serum homocysteine levels;Adverse events; | — |
Countries
China
Contacts
Public ContactZheng Bei
Geriatric Hospital of Hainan
Outcome results
None listed