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Infusion of urokinase DCD kidneys on renal function after transplantation randomized double-blind controlled study

A randomized, double-blind, controlled study of the effects of urokinase combined with lifeport on renal function after DCD donor kidney transplantation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900022532
Enrollment
Unknown
Registered
2019-04-15
Start date
2015-01-01
Completion date
Unknown
Last updated
2019-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

renal transplantation

Interventions

Experimental group:urokinase with Perfusion liquid foundation
Control group:Perfusion liquid foundation

Sponsors

USC of the Second Affiliated Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Donor: 1. donor age > 10 years old; 2. The donor kidney source is a cardiac death organ donation; 3. The donor's two kidneys were transplanted to two different recipients. Recipient: 1. Regular review and evaluation before surgery; 2. basic tests and examinations on the day before surgery; 3. no kidney transplant surgery taboo; 4. preoperative group reactive antibody (PRA) 10%.

Exclusion criteria

Exclusion criteria: Donor: 1. for renal artery or vein >=2 branches; Recipient: 1. number of transplants >1; 2. Patients died in the first week after transplantation (because the time to determine the primary endpoint of DGF was at least 1 week of follow-up).

Design outcomes

Primary

MeasureTime frame
The incidence of DGF;—

Secondary

MeasureTime frame
Cystatin;The incidence of acute rejection;Serum creatinine;Serum creatinine;—

Countries

China

Contacts

Public ContactZhigang Luo

USC of the Second Affiliated Hospital

706885399@qq.com+86 13907342350

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026