mild cognitive impariment/subjective cognitive decline
Conditions
Interventions
AD/MCI/pMCI/SCD/NC:none
Sponsors
Affiliated Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. diagnostic criteria determine into the group, at least 30 cases in each group. The groups were matched according to gender, age and education level; 2. subjects were recruited for the purpose of the study, and their cognitive level was determined by the following cognitive scores; 3. match each group according to gender, age and education level; 4. the assessment of the general cognitive rating scale was completed on the day of the MRI examination or within one week; 5. the project is carried out under mature diagnostic technology. The project is discussed and approved by the ethics committee of the hospital. Elderly patients who complain of cognitive abnormalities or voluntarily participate in the study are informed of the methods and safety issues of the study, and informed consent is obtained. (see attachment). 6. behavioral test should be completed on the same day, neuropsychological score should be completed within three days, and it should be completed by neurologists, geriatric neurologists and neurology graduate students in gulou hospital, and the disease diagnosis opinions should be signed for consultation. SCD diagnostic criteria: Meet Frank Jessen 2014 standard: (1) aged more than equal to 60 years old; (2) compared with the normal state in the past, the patient reported a decline in memory; (3) The standardized cognitive test results used to evaluate early MCI or AD were normal; (4) The second point and the third point must be satisfied at the same time; (5) exclusion: MCI, AD prodrome or dementia; Except by mental or neurological disease (AD), medical disease, drugs such as interpretation of disease. MCI diagnostic criteria: With reference to the 2001 quality standards subcommittee recommended by American society for neural Petersen standard proposed by 1999: (1) complained of a memory disorders, and insider confirmed; Objective evidence of memory impairment; (2) mild abnormalities in the overall cognitive rating scale (education age over 8 years) : MMSE 25 ~ 26 points; MoCA 19 ~ 25 points; CDR 0.5 points; Fares Hachinski ischemia (Rosen method) was less than or equal to 4 points, except for vascular dementia and mixed dementia. Daily life ability of normal or slightly damaged (20 ADL scale, normal 20 points); (3) MRI inclusion criteria: except for brain atrophy and a small amount of demyelinating lesions in deep white matter (Fazekas scale I and below), there were no other abnormal changes. Diagnostic criteria for progressive MCI: According to the literature of Petersen, R.C. (J Intern Med, 2004) and Whitwell JL (Brain, 2007), about 12 ~ 15% of aMCI progress to AD every year, and 80% of them are converted to AD after 6 years of follow-up. (1) been followed up for 6 years later diagnosed with AD or other types of dementia, the state before it into dementia can progress in diagnosis of MCI; (2) patients with MCI were followed up every year, and their MMSE scores continued to decline, down by more than 2 points. Probable AD: it is probable that the diagnostic and statistical manual of mental disorders, dsm-iv, and the nincds-adrda criteria will be considered. Objective evidence shows that there is short-term or long-term memory damage; (3) has the following eight cognitive areas of one or more cognitive dysfunction: memory, language, attention, executive ability, abstract thinking and judgment, directional force damage, other cortical function disorders, personality changes. These two types of cognitiv
Exclusion criteria
Exclusion criteria: Refer to National institutes of Health and Petersen et al.: (1) other dementia-related neurological diseases or previous depression within 2 years (HAMD score or higher; (2) any other significant systemic disease within the previous 5 years; (3) transient ischemic attack, subarachnoid hemorrhage, ischemic/hemorrhagic infarction, history of brain tumor And so on; (4) history of alcohol and drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI features;spatial navigation performance;Cognitions Scales; | — |
Countries
China
Contacts
Public ContactBing Zhang
Affiliated Drum Tower Hospital of Nanjing University Medical School
Outcome results
None listed