mild cognitive impariment
Conditions
Interventions
AD/pMCI/hMCI/NC:none
Sponsors
Affiliated Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: Probable AD: It is probable that the diagnostic and statistical manual of mental disorders, dsm-iv, and the nincds-adrda criteria will be considered. 1) objective evidence suggests short-term or long-term memory impairment. 2) one or more of the following cognitive dysfunction in eight cognitive regions: memory, language, attention, executive ability, orientation, impairment of abstract thinking and judgment, other cortical dysfunction, personality change; 3) the above two types of cognitive impairment significantly interfere with social, professional activities or interpersonal relationships; 4) abnormalities in the general cognitive rating scale (education age over 8 years): MMSE 24, 20-24 (mild), 16-19 (moderate), and below 15 (severe); MoCA 20, Hachinski ischemia index table 4; 5) right handedness and signing of the informed consent. 6) MRI inclusion criteria: except for brain atrophy and small amount of demyelinating lesions in deep white matter (Fazekas scale I). No other abnormal changes. Diagnostic criteria for MCI, refer to Petersen, 2001, recommended by the quality standards branch of the American neurological association: 1) chief complaint of cognitive dysfunction; Objective cognitive function task impaired performance. 2) mild abnormalities in the general cognitive rating scale (education age over 8 years): MMSE 25 ~ 26 points; MoCA 19 ~ 25 points; CDR 0.5 points; Hachinski ischemia index (Rosen method) score was less than or equal to 4, except vascular dementia and mixed dementia. Normal or minor impairment of daily living ability (20 items of ADL scale, normal score 20 points); 3) right handedness, and sign the informed consent; 4) MRI inclusion criteria were the same as before. HMCI diagnostic criteria: refer to Dubois, proposed based on (Grober and Buschke 16 - clues to enhance recall program testing, GB Test) 's standards. (all diagnostic criteria must be met simultaneously, the same below). Free recall was severely flawed (despite adequate coding) or impaired overall recall due to insufficient cue effects: less than 10 words, or more than 30% of 10 to 14 words were disordered spontaneous recall (a total of 16 words). It reflects the disorder of encoding and consolidation of memory, which is closely related to hippocampal function. NHMCI diagnostic criteria: refer to the criteria proposed by Dubois et al. (16-item enhanced cue recall procedure test based on Grober and Buschke, G B's Te st). (all diagnostic criteria must be met simultaneously, the same below). The degree of damage of free recall was less: no more than 30% of the disordered spontaneous recall in 10~14 words; Or they tended to be normal after giving clues: 15 to 16 words were recalled (a total of 16 words). It reflects the impairment of memory extraction and is closely related to the function of frontal lobe. Non-amnestic MCI- (naMCI) diagnostic criteria: refer to MCI diagnostic criteria. A) no chief complaint of memory disorder. B) attention - executive dysfunction, language or visuospatial dysfunction. Diagnostic criteria for progressive MCI: according to the literature of Petersen, R.C. (J Intern Med, 2004) and Whitwell JL (Brain, 2007), about 12 ~ 15% of the patients with aMCI developed into AD every year, and 80% of them were converted into AD after 6 years of follow-up. (1) in patients diagnosed with AD or other types of dementia after 6 years of follow-up, progress
Exclusion criteria
Exclusion criteria: Meet the standards proposed by the National Institute of Health and Petersen et al.: 1) other dementia-related neurological diseases or previous depression within 2 years (HAMD score 17); 2) any other significant systemic disease within the previous 5 years; 3) transient ischemic attack, subarachnoid hemorrhage, ischemic/hemorrhagic infarction, history of brain tumor, etc.; 4) history of alcohol and drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI features;spatial navigation performance;Cognitions Scales; | — |
Countries
China
Contacts
Public ContactBing Zhang
Affiliated Drum Tower Hospital of Nanjing University Medical School
Outcome results
None listed