intrauterine adhesion
Conditions
Interventions
Group 1:Intrauterine balloon placement
Group 2:Oral estrogen
Group 3:Intrauterine balloon placement+Oral estrogen
Group 4:Intrauterine balloon placement + vaginal viable lactobacillus crimp preparation
Group 5:Oral estrogen + vaginal viable lactobacillus crimp preparation
Group 6:Intrauterine balloon placement +Oral estrogen + vaginal viable lactobacillus crimp preparation
Sponsors
the Second Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Informed consent; 2. All patients were diagnosed with moderate to severe intrauterine adhesion by outpatient hysteroscopy (score 5 according to the American Fertility Society (AFS)); 3. There is no other abnormal condition of uterus in hysteroscopy;
Exclusion criteria
Exclusion criteria: 1. Menopause (FSH> 40 mIU/mL, 17 -estradiol < 20 pg/mL); 2. Antibiotics were used 1 month before surgery; 3. Contraindicated use of estrogen, such as breast cancer, endometrial cancer, high-risk groups of thrombotic diseases; 4. The patient has serious systemic diseases,such as evere heart, lung, kidney and liver dysfunction or metabolic diseases; 5. Patients who are allergic to probiotics; 6. Has surgical contraindication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recurrence rate;Changes in vaginal flora; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cervical and vaginal secretions;endometrial thickness;menstrual blood volume; | — |
Countries
China
Contacts
Public ContactZhaoxia Liu
the Second Affiliated Hospital of Nanchang University
Outcome results
None listed