Seronegative Hepatitis B Virus-associated Membranous Nephropathy
Conditions
Interventions
Case series:give corticosteroids(Methylprednisolone)
Sponsors
Tianjin Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) The presence of profound proteinuria >3.5 g/d and a serum albumin level <30 g/L with or without edema or hyperlipidemia; (2) Pathological diagnosis of renal biopsy was HBV-associated membranous nephropathy; (3) The absence of HBsAg, HBeAg, HBcAg and HBV-DNA replication in the serum; (4) No immunosuppressive agents, corticosteroids were allowed in the 3 months prior to the entry of the study; (5) Patients with normal renal function; (6) Male and female aged 18-80 years old; (7) Patients and their families signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Evidence of HBV antigen or HBV DNA in the serum; (2) Idiopathic membranous nephropathy and secondary membranous nephropathy except hepatitis B virus-associated membranous nephropathy; (3) Patients who does not meet the criterion of nephrotic syndrome; (4) Renal insufficiency with Scr>1.3mg/dl(115umol/L) at the beginning of treatment; (5) Patients with other diseases with an expected survival period of less than 2 years, such as tumors, AIDS and severe infections that cannot be controlled; (6) Plasma exchange, immunosuppressive agents, corticosteroids, CTX and other cytotoxic drugs were performed in the 3 months prior to the entry of the study; (7) Pregnant or lactating patients; (8) Patients with mental disorders or incapacitated patients; (9) Poor drug compliance; (10) Patients who can not promise to have a regular follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24 hours urinary protein quantity;Serum albumin;Serum creatinine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood urea nitrogen;Uric acid;Triglyceride;Cholesterin; | — |
Countries
China
Contacts
Public ContactDingwei Yang
Tianjin Hospital
Outcome results
None listed